Differences Between Chickenpox and Smallpox
| S.N. | Characteristics | Chickenpox | Smallpox |
|---|---|---|---|
| 1 | Causative Agent | Varicella Zoster Virus (Herpes Virus) | Variola virus (Pox Virus) |
| 2 | Incubation period | 14-21 days | 7-17 days |
| 3 | Severity | Chickenpox is less deadly comparing to small pox. | Smallpox is deadly severe comparing to chicken pox. |
| 4 | Lesions | Lesions first appear on the face or trunk. | Lesions first appear in the throat or mouth, then on the face, or on the upper arms. |
| 5 | Rash Lesions | Lesions develop in successive fashion. While some are new, others are crusting over (in “crops”). | Lesions develop at the same time, and they look alike on any one section of the body, such as the abdomen, arms, or face. |
| 6 | Initial Symptoms | 0 to 2 days of mild illness pass before the rash develops. | 2 to 3 days of severe illness pass before the rash develops. |
| 7 | Rash Lesions | Lesions change rapidly, crusting over within 24 hours. | Lesions change slowly, scabbing over after 9 to 15 days. |
| 8 | Rash Lesions | Lesions sit on the skin surface and look like small blisters. | Lesions become firm, dome-shaped, and deep in the skin. |
| 9 | Rash Lesions | Rash rarely develops on palms and soles. | Rash commonly develops on palms of the hands and soles of the feet. |
| 10 | Rash Lesions | Lesions are most concentrated on the torso, with fewest on the hands and feet. Lesions can affect the face and scalp, but rarely affect the entire body equally. | Lesions are most concentrated on the face, hands, and feet. |
| 11 | Rash Lesions | No illness precedes the chickenpox rash. | Malaise, fever, rigors, vomiting, headache and backache precede the rash by two to three days. |
| 12 | Scabs | Scabs that are not infectious begin to form four to seven days after the rash appears. | Scabs that can be infectious begin to form 10 to 14 days after the rash appears. |
| 13 | Scabs | Scabs fall off within 14 days after the rash begins. | Scabs fall off 14 to 28 days after the rash begins. |
| 14 | Pocks | Pocks are more superficial. | Pocks are buried deep in the dermis. |
| 15 | Vesicles | Vesicles collapse on puncture. | Vesicles do not collapse on puncture. |
| 16 | Evolution of Pocks | Asynchronous | Synchronous |
| 17 | Prevalence | Chickenpox is still prevailing. | Smallpox has been eradicated from the earth. |
| 18 | Fever | Fever occurs with each crop of vesicles | Fever subsides with development of rash,
may appear again with formation of pustules (secondary rise of temperature) |


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